Physical Constraints on Proteomes Impose Limits to Biological Evolution
نویسندگان
چکیده
منابع مشابه
Physical limits of cells and proteomes.
What are the physical limits to cell behavior? Often, the physical limitations can be dominated by the proteome, the cell's complement of proteins. We combine known protein sizes, stabilities, and rates of folding and diffusion, with the known protein-length distributions P(N) of proteomes (Escherichia coli, yeast, and worm), to formulate distributions and scaling relationships in order to addr...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.2381